Targeting Kinases in Fasciola hepatica: Anthelminthic Effects and Tissue Distribution of Selected Kinase Inhibitors

Fasciola hepatica

18 The success of helminth parasites is partly related to their ability to modulate host immune 19 responses towards an anti-inflammatory/regulatory phenotype. This ability resides with the 20 molecules contained in the secretome of various helminths that have been shown to interact with 21 host immune cells and influence their function. Consequently, there exists a unique opportunity 22 to exp...

Molecular Cloning and Characterisation of Phosphoglycerate Kinase from Fasciola Hepatica

This paper is focused on cloning and bioinformatical as well as immunological characterisation of the new vaccine antigen candidate against fasciolosis – Fasciola hepatica phosphoglycerate kinase (FhPGK). The antigen was cloned from the adult fluke by the use of RACE-PCR method. It was found that FhPGK is not a secretory and not a stage specific protein. It is present in all kinds of parasite t...

Determination of somatic and excretory-secretory antigens of Fasciola hepatica and Fasciola gigantica using SDS-PAGE

Human fascioliasis due to unknown species and animal fascioliasis caused by both or one of Fasciola spp. are commonly seen in Iran. To compare electrophoretic patterns of somatic and excretory-secretory antigens of F. hepatica and F. gigantica  by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE), the adult flukes were collected from infected slaughtered bovine livers. E/S a...

Fasciola hepatica infection in China.

Fasciola hepatica is one of the most common parasites in China that infects ruminants, especially cattle, sheep and goats, and causes considerable morbidity and economic losses in the animal husbandry. The climate in wide areas of China is suitable for the development of F. hepatica and its intermediate snail hosts. However, human infection with the fluke is not common. Up to now, 38 hospital p...

The efficiency of diamphenethide against Fasciola hepatica in sheep